Ruth A. Schwalbe, PhD
Associate Professor
Brody 5S-36
The Brody School of Medicine at East Carolina University
Greenville, NC 27834
phone: 252-744-2034
email: schwalber@ecu.edu
Education
- B.S., Phillips Univ., 1983
- B.S., Univ. of Minnesota, 1989
- M.S., Univ. Minnesota, 1990
- Ph.D., Univ. of Minnesota, 1993
- Post-doctorate, Baylor College of Medicine
- Post-doctorate, Case Western Reserve Univ/MHMC
- Junior Staff Scientist, Rammelkamp Institure of Research
- Research Assistant Prof., Univ. of Florida
Research Interests
Research in the Schwalbe lab consists of two projects comprised of both cellular and organismal models to examine the effects of aberrant N-glycosylation. One project addresses defective N-glycosylation and its involvement in the development and maintenance of zebrafish (a vertebrate model). Specifically, we examine neurogenesis, neural structure/function, complications associated with neurological difficulties, and behavior during the lifespan of the fish. The second project focuses on the relationship of N-glycans and aberrant neuronal behavior associated with neuroblastoma. CRISPR/Cas9 technology is employed to inactivate genes in the N-glycosylation pathway to create mutant zebrafish strains and neuroblastoma cell lines. Biochemical, cellular, molecular and behavior techniques are applied to examine wild type and mutant organismal and cell models.
Funded Project
Wooten Family Initiative for Brain Health Research Grant, 2023-2024, Title: “Relating N-glycans to neural development and neurological problems”
Recently Funded Project
National Institute of HealthGM129679, 2018-2022, Title: “Roles of N-glycans on potassium channels”
Selected Publications
View list of selected publications (PDF)
View complete PubMed listing for Schwalbe RA