Brian M. Shewchuk, PhD
Associate Professor
Brody 5W-52
The Brody School of Medicine at East Carolina University
Greenville, NC 27834
phone: 252-744-5096
email: shewchukb@ecu.edu
Education
- B.S., Rochester Institute of Technology, 1991
- Ph.D., Pennsylvania State University, 1997
- Postdoctoral fellowship, University of Pennsylvania
Research Interests
- Molecular Biology of gene regulation
- Chromatin structure and modification
- Epigenetic processes in disease
Selected Publications
Shaikh, S., P. Shaver and B. Shewchuk (2018) High fat diet dysregulates hypothalamic-pituitary axis gene expression levels which are differentially rescued by EPA and DHA ethyl esters. Molecular Nutrition and Food Research doi.org/10.1002/mnfr.201800219
Wang, L., S. DeMarco, M. Sanderson, A. Maiorana-Boutilier, J. Chen, M. Crouch, B. Shewchuk, S. Shaikh, C. Phillips and L. Bridges (2017)RARĪ±/RXR synergism potentiates retinoid responsiveness in cutaneous T-celllymphoma cell lines. Experimental Dermatology 26:1004-1011
Holt, A., D. Martin, P. Shaver, S. Adderley, J. Stone, C.Joshi1, J. Francisco, R. Lust, D. Widener, B. Shewchuk and D. Tulis (2016)Soluble guanylyl cyclase-activated cyclic GMP-dependent protein kinase inhibits arterial smooth muscle cell migration independent of VASP-serine 239 phosphorylation. Cellular Signaling 28:1364-79.
Shewchuk, B. Epigenetics and Obesity. In D. Yasui, J. Peedicayil and D. Grayson (Eds.), Neurobehavioral Disorders and Epigenetics. 2016Academic Press. Amsterdam, NL: Elsevier.
Maples, J., J. Brault, C. Witczak, S. Park, M. Hubal, T.Weber, J. Houmard and B. Shewchuk (2015) Differential Epigenetic and Transcriptional Response of the Skeletal Muscle Carnitine Palmitoyltransferase1B (CPT1B) Gene to Lipid Exposure with Obesity. AJP Endocrinology & Metabolism, 309:E345-56.
Maples, J., J. Brault, B. Shewchuk, C. Witczak, M. Hubal, T. Weber and J. Houmard (2015) Lipid exposure elicits differential responses in gene expression and DNA methylation in the skeletal muscle of obese individuals. Physiological Genomics, 47:139-46.
Shewchuk, B. (2014) Prostaglandins and n-3 polyunsaturated fatty acids in the regulation of the hypothalamic-pituitary axis. Prostaglandins, Leukotrienes and Essential Fatty Acids 91:277-287.
B. Patel, F. Yao, A. Howenstine, R. Takenaka, J. Hyatt, K. Sears and B. Shewchuk (2020) Emergent Coordination of the CHKB and CPT1B Genes in Eutherian Mammals: Implications for the Origin of Brown Adipose Tissue. Journal of Molecular Biology doi.org/10.1016/j.jmb.2020.09.022.